Oxidative Stress in Kidney Diseases: The Cause or the Consequence?

Arch Immunol Ther Exp (Warsz). 2018 Jun;66(3):211-220. doi: 10.1007/s00005-017-0496-0. Epub 2017 Dec 6.


Exaggerated oxidative stress (OS) is usually considered as a disturbance in regular function of an organism. The excessive levels of OS mediators may lead to major damage within the organism's cells and tissues. Therefore, the OS-associated biomarkers may be considered as new diagnostic tools of various diseases. In nephrology, researchers are looking for alternative methods replacing the renal biopsy in patients with suspicion of chronic kidney disease (CKD). Currently, CKD is a frequent health problem in world population, which can lead to progressive loss of kidney function and eventually to end-stage renal disease. The course of CKD depends on the primary disease. It is assumed that one of the factors influencing the course of CKD might be OS. In the current work, we review whether monitoring the OS-associated biomarkers in nephrology patients can support the decision-making process regarding diagnosis, prognostication and treatment initiation.

Keywords: Biomarkers; Chronic kidney disease; Oxidative stress.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers / metabolism
  • Clinical Decision-Making
  • Disease Progression
  • Homeostasis
  • Humans
  • Kidney Diseases / diagnosis*
  • Kidney Diseases / therapy
  • Oxidation-Reduction*
  • Oxidative Stress*
  • Prognosis


  • Biomarkers