Cohesin: building loops, but not compartments

EMBO J. 2017 Dec 15;36(24):3549-3551. doi: 10.15252/embj.201798654. Epub 2017 Dec 7.


DNA is subjected to major cellular events, such as transcription, replication and DNA repair. To control these processes, the architecture of the DNA is tightly regulated. Recent work, including two studies in this issue of The EMBO Journal, provides compelling evidence that cohesin structures chromosomes through the processive enlargement of loops. While cohesin promotes chromosomal looping, it rather counteracts nuclear compartmentalization.

Publication types

  • Comment

MeSH terms

  • Cell Cycle Proteins*
  • Chromosomal Proteins, Non-Histone*
  • Humans


  • Cell Cycle Proteins
  • Chromosomal Proteins, Non-Histone
  • cohesins