Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient

R Slim; N Asmar; C Yaghi; K Honein; R Sayegh; D Chelala

doi:10.4103/ijn.IJN_339_16

Trimethoprim-Sulfamethoxazole-induced Hepatotoxicity in a Renal Transplant Patient

Indian J Nephrol. 2017 Nov-Dec;27(6):482-483. doi: 10.4103/ijn.IJN_339_16.

Authors

R Slim¹, N Asmar¹, C Yaghi¹, K Honein¹, R Sayegh¹, D Chelala²

Affiliations

¹ Department of Gastroenterology, Hotel-Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.
² Department of Nephrology, Hotel-Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon.

Abstract

Drug-induced liver injury (DILI) represents liver damage from various therapeutic drugs. Antimicrobials are among the most common causes of DILI. We report a case of hepatic toxicity due to Trimethoprim-sulfamethoxazole (TMP-SMX) in a patient who underwent renal transplantation. Diagnosis has been made after a careful history taking, exclusion of competing etiologies and reversal of biochemical abnormalities after withdrawal of the antibiotic. TMP-SMX liver toxicity is well known but remains unpredictable and is rarely reported.

Keywords: Hepatotoxicity; renal transplant; trimethoprim-sulfamethoxazole.

Publication types

Case Reports