Total Synthesis of Huperzine R

Org Lett. 2018 Jan 5;20(1):119-121. doi: 10.1021/acs.orglett.7b03555. Epub 2017 Dec 8.


A total synthesis of huperzine R was accomplished. Intramolecular cycloaddition of a nitrile oxide and reductive cleavage of the resulting isoxazoline induced sequential cleavage of the C-C and C-O bonds to form the characteristic bicyclic lactam core with an enone moiety. Construction of the butenolide moiety from the enone afforded huperzine R.

Publication types

  • Research Support, Non-U.S. Gov't