Structure of tumour necrosis factor

Nature. 1989 Mar 16;338(6212):225-8. doi: 10.1038/338225a0.


Tumour necrosis factor is a trimeric molecule, each subunit of which consists of an antiparallel beta-sandwich. Individual subunits from the trimer by a novel edge-to-face packing of beta-sheets. A comparison of the subunit fold with that of other proteins reveals a remarkable similarity to the 'jelly-roll' structural motif characteristic of viral coat proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Structure*
  • Protein Conformation
  • Tumor Necrosis Factor-alpha*


  • Tumor Necrosis Factor-alpha