Replication Fork Reversal: Players and Guardians

Mol Cell. 2017 Dec 7;68(5):830-833. doi: 10.1016/j.molcel.2017.11.022.


Replication fork reversal is a rapidly emerging and remarkably frequent mechanism of fork stabilization in response to genotoxic insults. Here, we summarize recent findings that uncover key molecular determinants for reversed fork formation and describe how the homologous recombination factors BRCA1, BRCA2, and RAD51 protect these structures from extended nucleolytic degradation.

Keywords: BRCA1; BRCA2; DNA repair; DNA replication; fork regression; genome instability; homologous recombination; replication fork restart; replication fork reversal; replication stress.

Publication types

  • Review

MeSH terms

  • Animals
  • BRCA1 Protein / genetics
  • BRCA1 Protein / metabolism*
  • BRCA2 Protein / genetics
  • BRCA2 Protein / metabolism*
  • DNA / biosynthesis*
  • DNA / genetics
  • DNA Damage*
  • DNA Replication*
  • Humans
  • Rad51 Recombinase / genetics
  • Rad51 Recombinase / metabolism*
  • Recombinational DNA Repair*


  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human
  • DNA
  • RAD51 protein, human
  • Rad51 Recombinase