Global burden of molar incisor hypomineralization

Falk Schwendicke; Karim Elhennawy; Seif Reda; Katrin Bekes; David J Manton; Joachim Krois

doi:10.1016/j.jdent.2017.12.002

Global burden of molar incisor hypomineralization

J Dent. 2018 Jan:68:10-18. doi: 10.1016/j.jdent.2017.12.002. Epub 2017 Dec 6.

Authors

Falk Schwendicke¹, Karim Elhennawy², Seif Reda², Katrin Bekes³, David J Manton⁴, Joachim Krois²

Affiliations

¹ Operative and Preventive Dentistry, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany. Electronic address: falk.schwendicke@charite.de.
² Operative and Preventive Dentistry, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.
³ Department of Paediatric Dentistry, School of Dentistry, Medical University of Vienna, Vienna, Austria.
⁴ Paediatric Dentistry, Melbourne Dental School, University of Melbourne, Australia.

PMID: 29221956
DOI: 10.1016/j.jdent.2017.12.002

Abstract

Objectives: We aimed to systematically review and meta-analyze the global, super-regional, regional and national prevalence of molar-incisor-hypomineralization (MIH) and to determine the numbers of prevalent and incident cases on different spatial scales. The review was registered (PROSPERO CRD42017063842).

Sources: Five electronic databases (Medline, EMBASE, LILACS, Web of Science, Google Scholar) were searched systematically.

Study selection: Observational studies on the prevalence of MIH were included and the prevalence on different spatial scales (global, super-regional, regional, national) synthesized using random-effects meta-analyses. The prevalence was then regressed on a large set of methodological, socioeconomic and environmental variables to estimate the global burden (incident and prevalent cases) of MIH.

Data: Of 2239 identified studies, 99 studies on 113,144 participants from 43 countries were included. The meta-analysis yielded a mean (95% CI) prevalence of 13.1% (11.8-14.5%), with significant differences between super-regions, regions and countries. The number of prevalent cases in 2015 was estimated at 878 (791-971) million people, while the number of incident cases in 2016 was 17.5 (15.8-19.4) million. Of these, 27.4% (23.5-31.7%) (in mean, 240 million prevalent and 4.8 million incident cases, respectively) were or will be in need of therapy due to pain, hypersensitivity or posteruptive breakdown. Heavily populated countries contribute significantly to the burden of prevalent cases, while growing countries like India, but also Pakistan or Indonesia rank first with respect to the number of incident cases.

Conclusions: MIH is highly prevalent across the globe. Certain (mainly low- and middle income) countries shoulder the majority of this burden. Clinical significance The consistently high prevalence and the large proportion of cases in need of care should be considered by both clinicians in their daily practice and healthcare planners and policy makers.

Keywords: Biostatistics; Dental public health; Epidemiology; Meta-analysis.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

MeSH terms

Administrative Personnel
Biostatistics
Databases, Factual
Dental Enamel Hypoplasia / epidemiology*
Dental Enamel Hypoplasia / physiopathology
Global Health / statistics & numerical data*
Humans
Prevalence
Public Health