Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007

Xiaoyan Pang; Xiuping Lin; Junfeng Wang; Rui Liang; Yongqi Tian; Limbadri Salendra; Xiaowei Luo; Xuefeng Zhou; Bin Yang; Zhengchao Tu; Yonghong Liu

doi:10.1016/j.steroids.2017.12.001

Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007

Steroids. 2018 Jan:129:41-46. doi: 10.1016/j.steroids.2017.12.001. Epub 2017 Dec 6.

Authors

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China; University of Chinese Academy of Sciences, Beijing, China.
² CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
³ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China. Electronic address: wangjunfeng@scsio.ac.cn.
⁴ Laboratory of Molecular Engineering and Laboratory of Natural Product Synthesis, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
⁵ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China; University of Chinese Academy of Sciences, Beijing, China; South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, China. Electronic address: yonghongliu@scsio.ac.cn.

PMID: 29223616
DOI: 10.1016/j.steroids.2017.12.001

Abstract

Three new highly oxygenated sterols (1-3) and a new dihydroisocoumarin (7) together with six known compounds were isolated from the extracts of the culture of a sponge-derived fungus Cladosporium sp. SCSIO41007. The structures of all new compounds (1-3, 7) were determined by the extensive spectroscopic analysis including NMR, MS, IR, and UV. Their absolute configurations were determined by X-ray single-crystal and CD data analysis. Compound 2 exhibited weak inhibitory activity against H3N2 with the IC₅₀ value of 16.2 μM.

Keywords: Antiviral; Cladosporium sp.; Sponge-derived fungus; Sterols.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Antiviral Agents / chemistry
Antiviral Agents / pharmacology
Cell Line, Tumor
Chlorocebus aethiops
Cladosporium / chemistry*
Coumarins / chemistry*
Coumarins / pharmacology*
Humans
Influenza A Virus, H3N2 Subtype / drug effects
Oxygen / chemistry*
Porifera / microbiology*
Sterols / chemistry*
Sterols / pharmacology*
Vero Cells

Substances

Antineoplastic Agents
Antiviral Agents
Coumarins
Sterols
Oxygen