Comparison of Muscle Mass Indices Using Computed Tomography or Dual X-Ray Absorptiometry for Predicting Physical Performance in Hemodialysis Patients

Kidney Blood Press Res. 2017;42(6):1119-1127. doi: 10.1159/000485779. Epub 2017 Dec 7.


Background/aims: Our study aims to evaluate the association between thigh muscle cross-sectional area (TMA) using computed tomography (CT), or appendicular skeletal muscle mass (ASM) using dual energy X-ray absorptiometry (DEXA), and physical performance levels in hemodialysis (HD) patients.

Methods: Patients were included if they were on HD for ≥6 months (n = 84). ASM and TMA were adjusted to body weight (BW, kg) or height2 (Ht2, m2). Each participant performed a short physical performance battery test (SPPB), a sit-to-stand for 30 second test (STS30), a 6-minute walk test (6-MWT), a timed up and go test (TUG), and hand grip strength (HGS) test.

Results: Correlation coefficients for SPPB, GS, 5STS, STS30, 6-MWT, and TUG were highest in TMA/BW. Results from partial correlation or linear regression analyses displayed similar trends to those derived from Pearson's correlation analyses. An increase in TMA/BW or TMA/Ht2 was associated with a decreased odds ratio of low SPPB, GS, or HGS in multivariate analyses. Indices using DEXA were associated with a decreased odds ratio of a low HGS only in multivariate analysis.

Conclusion: TMA indices using CT may be more valuable in predicting physical performance or strength in HD patients.

Keywords: Appendicular muscle mass; Hemodialysis; Physical performance; Thigh muscle cross-sectional area.

Publication types

  • Comparative Study

MeSH terms

  • Absorptiometry, Photon / methods*
  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscle, Skeletal / physiology*
  • Organ Size
  • Physical Fitness*
  • Prognosis
  • Renal Dialysis
  • Renal Insufficiency, Chronic / physiopathology*
  • Thigh / physiology
  • Tomography, X-Ray Computed / methods*