The Role of Estrogens in Pancreatic Islet Physiopathology

Adv Exp Med Biol. 2017;1043:385-399. doi: 10.1007/978-3-319-70178-3_18.

Abstract

In rodent models of insulin-deficient diabetes, 17β-estradiol (E2) protects pancreatic insulin-producing β-cells against oxidative stress, amyloid polypeptide toxicity, gluco-lipotoxicity, and apoptosis. Three estrogen receptors (ERs)-ERα, ERβ, and the G protein-coupled ER (GPER)-have been identified in rodent and human β-cells. This chapter describes recent advances in our understanding of the role of ERs in islet β-cell function, nutrient homeostasis, survival from pro-apoptotic stimuli, and proliferation. We discuss why and how ERs represent potential therapeutic targets for the maintenance of functional β-cell mass.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Blood Glucose / metabolism
  • Cell Proliferation
  • Diabetes Mellitus, Experimental / metabolism
  • Diabetes Mellitus, Experimental / pathology
  • Diabetes Mellitus, Experimental / physiopathology
  • Diabetes Mellitus, Type 1 / metabolism*
  • Diabetes Mellitus, Type 1 / pathology
  • Diabetes Mellitus, Type 1 / physiopathology
  • Diabetes Mellitus, Type 1 / therapy
  • Estradiol / adverse effects
  • Estrogen Replacement Therapy* / adverse effects
  • Estrogens / adverse effects
  • Estrogens / metabolism*
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin / metabolism*
  • Insulin Secretion
  • Islets of Langerhans / metabolism*
  • Islets of Langerhans / pathology
  • Islets of Langerhans / physiopathology
  • Islets of Langerhans / surgery
  • Islets of Langerhans Transplantation
  • Ligands
  • Mice, Inbred NOD
  • Nutritional Status
  • Receptors, Estrogen / drug effects
  • Receptors, Estrogen / metabolism*
  • Risk Factors
  • Signal Transduction

Substances

  • Blood Glucose
  • Estrogens
  • Hypoglycemic Agents
  • Insulin
  • Ligands
  • Receptors, Estrogen
  • Estradiol