Re-irradiation and Hyperthermia in Breast Cancer

Clin Oncol (R Coll Radiol). 2018 Feb;30(2):73-84. doi: 10.1016/j.clon.2017.11.004. Epub 2017 Dec 8.


Half of locoregional recurrences after breast cancer treatment are isolated events. Restaging should be carried out to select patients for curative salvage treatment. The approach depends on the characteristics of the primary and recurrent cancer, previous locoregional and systemic treatments, site of recurrence, comorbidities and the patient's wishes. A multidisciplinary discussion should be associated with the shared decision-making process. In view of the potential long-term disease-free survival, meticulous target volume delineation and selection of the most appropriate techniques should be used to decrease the risk of toxicity. This overview aims to provide clinicians with tools to manage the different scenarios of breast cancer patients with locoregional recurrences in the context of re-irradiation.

Keywords: Breast cancer; chest wall recurrence; hyperthermia; re-irradiation; second breast-conserving therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / radiotherapy*
  • Combined Modality Therapy
  • Decision Making
  • Disease-Free Survival
  • Female
  • Humans
  • Hyperthermia, Induced
  • Neoplasm Recurrence, Local / radiotherapy*
  • Progression-Free Survival
  • Re-Irradiation / methods*
  • Salvage Therapy / methods