This study was set up to investigate whether work in car repair workshops is associated with an increased risk of ischemic heart disease and specific malignant neoplasms. For this purpose, a cohort of auto mechanics has been followed through 10 years with regard to cause-specific mortality. Comparisons were made with another cohort of skilled male workers who were not exposed to asbestos or petrochemical substances. The auto mechanics' mortality was increased for ischemic heart disease [standardized mortality ratio (SMR) 121, 95% confidence interval (95% CI) 102-145], other cardiovascular diseases (SMR 112, 95% CI 82-150), cancer (SMR 115, 95% CI 97-136), other diseases (SMR 119, 95% CI 94-149), and external causes (SMR 131, 95% CI 113-153). For specific cancer sites, increases were seen for pancreatic cancer, urinary cancer outside the bladder, and pleural mesothelioma.