Bioactive Peptides Derived from Seaweed Protein and Their Health Benefits: Antihypertensive, Antioxidant, and Antidiabetic Properties

J Food Sci. 2018 Jan;83(1):6-16. doi: 10.1111/1750-3841.14011. Epub 2017 Dec 11.


Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein-derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed. Bioactive peptides have strong potential for use in therapeutic drug and functional food formulation in health management strategy, especially cardiovascular disease and diabetes. Seaweeds can be used as sustainable protein sources in the production of these peptide-based drugs and functional foods for preventing such diseases. Many studies have reported that peptides showing angiotensin converting enzyme inhibition, antihypertensive, antioxidative and antidiabetics activities, have been successfully isolated from seaweed. However, further research is needed in large-scale production of these peptides, efficient isolation methods, interactions with functional foods and other pharmaceuticals, and their ease to digestion in in vivo studies and safety to validate the health benefits of these peptides.

Keywords: antidiabetic properties; antihypertensive effect; antioxidant activity; bioactive peptides; seaweed.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Animals
  • Antihypertensive Agents* / therapeutic use
  • Antioxidants* / therapeutic use
  • Cardiovascular Diseases / prevention & control
  • Diabetes Mellitus / prevention & control
  • Functional Food
  • Humans
  • Hypertension / prevention & control
  • Hypoglycemic Agents* / therapeutic use
  • Peptides / chemistry
  • Peptides / isolation & purification*
  • Peptides / therapeutic use*
  • Seaweed / chemistry*


  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Antioxidants
  • Hypoglycemic Agents
  • Peptides