Small Bioactive Peptides for Biomaterials Design and Therapeutics

Chem Rev. 2017 Dec 27;117(24):14015-14041. doi: 10.1021/acs.chemrev.7b00522. Epub 2017 Dec 11.

Abstract

This review is aimed to provide a concise yet extensive survey of key short bioactive peptide sequences for a range of applications ranging from biomaterials development to peptides with therapeutic uses. The following are considered: cell adhesion motifs, structural peptides, cell-penetrating and tumor-homing peptides, antimicrobial peptides, peptide hormones, growth factors and matrix metalloprotease substrates, neuropeptides, amyloid peptides, antioxidant peptides, peptide affinity tags, anticancer peptides, and others. This review provides a convenient resource, summarizing a broad range of important sequences with great utility as a resource concerning both small peptide drugs and also novel biofunctional peptide-based materials.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid / chemistry
  • Amyloid / metabolism
  • Antimicrobial Cationic Peptides / chemistry
  • Antimicrobial Cationic Peptides / metabolism
  • Antimicrobial Cationic Peptides / therapeutic use
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / therapeutic use
  • Antioxidants / chemistry
  • Antioxidants / metabolism
  • Antioxidants / therapeutic use
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism*
  • Biocompatible Materials / therapeutic use
  • Cell-Penetrating Peptides / chemistry
  • Cell-Penetrating Peptides / metabolism
  • Humans
  • Peptide Hormones / chemistry
  • Peptide Hormones / metabolism
  • Peptide Hormones / therapeutic use
  • Peptides / chemistry
  • Peptides / metabolism*
  • Peptides / therapeutic use
  • Tissue Engineering

Substances

  • Amyloid
  • Antimicrobial Cationic Peptides
  • Antineoplastic Agents
  • Antioxidants
  • Biocompatible Materials
  • Cell-Penetrating Peptides
  • Peptide Hormones
  • Peptides