Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study

J Evid Based Complementary Altern Med. 2017 Oct;22(4):816-823. doi: 10.1177/2156587217743640. Epub 2017 Dec 4.


Intake of oral supplements with the aim of a cutaneous antiaging effect are increasingly common. Hyaluronic acid (HA) is a promising candidate, as it is the key factor for preserving tissue hydration. In our practice study, we evaluated the effect of an oral HA preparation diluted in a cascade-fermented organic whole food concentrate supplemented with biotin, vitamin C, copper, and zinc (Regulatpro Hyaluron) on skin moisture content, elasticity, skin roughness, and wrinkle depths. Twenty female subjects with healthy skin in the age group of 45 to 60 years took the product once daily for 40 days. Different skin parameters were objectively assessed before the first intake, after 20 and after 40 days. Intake of the HA solution led to a significant increase in skin elasticity, skin hydration, and to a significant decrease in skin roughness and wrinkle depths. The supplement was well tolerated; no side effects were noted throughout the study.

Keywords: elasticity; hyaluronic acid; hydration; skin roughness; wrinkle reduction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Ascorbic Acid* / administration & dosage
  • Ascorbic Acid* / adverse effects
  • Biotin* / administration & dosage
  • Biotin* / adverse effects
  • Copper* / administration & dosage
  • Copper* / adverse effects
  • Dietary Supplements
  • Drug Combinations
  • Female
  • Humans
  • Hyaluronic Acid* / administration & dosage
  • Hyaluronic Acid* / adverse effects
  • Middle Aged
  • Rejuvenation
  • Skin Aging / drug effects*
  • Treatment Outcome
  • Zinc* / administration & dosage
  • Zinc* / adverse effects


  • Drug Combinations
  • Biotin
  • Copper
  • Hyaluronic Acid
  • Zinc
  • Ascorbic Acid