Repetitive weight loss and weight regain: effects on weight reduction, resting metabolic rate, and lipolytic activity before and after exercise and/or diet treatment

Am J Clin Nutr. 1989 Mar;49(3):409-16. doi: 10.1093/ajcn/49.3.409.


Body composition, maximal aerobic power (VO2 max), resting metabolic rate (RMR), and lipolytic activity of abdominal adipocytes were measured in 20 women (body mass index [BMI] = 33.5) during 14 wk of exercise training (4 h/wk at 60% of VO2 max) and dietary restriction (840 kcal/d). Frequent dieters (yo-yo) and women without a dietary history (non-yo-yo) were matched into the following groups: diet-exercise yo-yo (DE-Y), diet-exercise non-yo-yo (DE-NY), and diet-non-yo-yo group (D-NY). After 14 wk significant differences in weight loss and fat loss were revealed between D and DE groups but not between yo-yo and non-yo-yo dieters. RMR decreased in all groups but there was a significantly smaller decline after 14 wk for the diet-exercise groups. No effects of frequent dieting or exercise on basal and stimulated lipolytic activity were observed.

MeSH terms

  • Adult
  • Diet, Reducing*
  • Exercise*
  • Female
  • Humans
  • Lipolysis*
  • Obesity / diet therapy
  • Obesity / metabolism
  • Obesity / therapy*
  • Weight Gain
  • Weight Loss*