Evidence for a physiological role for CCK in the regulation of food intake in mice

Am J Physiol. 1989 Mar;256(3 Pt 2):R646-52. doi: 10.1152/ajpregu.1989.256.3.R646.


The effects of L-364,718, a cholecystokinin receptor antagonist, on cholecystokinin octapeptide-induced inhibition of food, and its effect on food intake when given alone, were studied in mice using several different feeding paradigms. In all studies, L-364,718 (100 micrograms/kg, 1.0 mg/kg) reversed the ability of cholecystokinin octapeptide to decrease food intake. L-364,718 enhanced food consumption compared with controls in nonfasted mice (100 microgram/kg) and in prefed mice (50, 100, 250 micrograms/kg). The number of reinforcements, using a lever press, was also enhanced by L-364,718 (100 micrograms/kg) compared with control. In other paradigms, L-364,718 failed to enhance food intake. These results are compatible with the suggestion that cholecystokinin may play a physiological role in the regulation of food intake.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Benzodiazepinones / pharmacology*
  • Cholecystokinin / antagonists & inhibitors*
  • Cholecystokinin / physiology
  • Devazepide
  • Fasting
  • Feeding Behavior / drug effects*
  • Homeostasis
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred Strains
  • Reference Values


  • Benzodiazepinones
  • Cholecystokinin
  • Devazepide