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Review
. 2017 Dec;49:53-58.
doi: 10.1016/j.ceb.2017.11.011. Epub 2017 Dec 9.

The Phenomenology of Cell Size Control

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Review

The Phenomenology of Cell Size Control

Kurt M Schmoller. Curr Opin Cell Biol. .

Abstract

Cells control their size through an intricate balance of cell growth, cell division, and cell death. Extensive work on unicellular model organisms revealed that cell-size-dependent cell cycle progression accounts for major aspects of cell size regulation and provided insights into the underlying molecular mechanisms. Nevertheless, elaborate live-cell imaging approaches still reveal new phenomenological observations that challenge our simplified models of size regulation and raise the question of what determines optimal cell size. Here, I aim to give a conceptual overview of the many processes contributing to cell size regulation and summarize recent developments in the field.

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