Analgesic-Like Activity of Essential Oil Constituents: An Update

Int J Mol Sci. 2017 Dec 9;18(12):2392. doi: 10.3390/ijms18122392.


The constituents of essential oils are widely found in foods and aromatic plants giving characteristic odor and flavor. However, pharmacological studies evidence its therapeutic potential for the treatment of several diseases and promising use as compounds with analgesic-like action. Considering that pain affects a significant part of the world population and the need for the development of new analgesics, this review reports on the current studies of essential oils' chemical constituents with analgesic-like activity, including a description of their mechanisms of action and chemical aspects.

Keywords: analgesic; antinociceptive; aromas; flavor; food; medicinal plants; natural products; phenylpropanoid; terpenes; volatile.

Publication types

  • Review

MeSH terms

  • Analgesics / chemistry
  • Analgesics / therapeutic use*
  • Animals
  • Burseraceae / chemistry
  • Food
  • Humans
  • Lamiaceae / chemistry
  • Molecular Structure
  • Oils, Volatile / chemistry
  • Oils, Volatile / therapeutic use*
  • Pain / drug therapy*


  • Analgesics
  • Oils, Volatile