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Randomized Controlled Trial
. 2017 Dec 12;17(1):290.
doi: 10.1186/s12872-017-0717-9.

Stroke Prevention Rehabilitation Intervention Trial of Exercise (SPRITE) - A Randomised Feasibility Study

Free PMC article
Randomized Controlled Trial

Stroke Prevention Rehabilitation Intervention Trial of Exercise (SPRITE) - A Randomised Feasibility Study

Neil Heron et al. BMC Cardiovasc Disord. .
Free PMC article


Background: The value of cardiac rehabilitation (CR) after a transient ischaemic attack (TIA) or minor stroke is untested despite these conditions sharing similar pathology and risk factors to coronary heart disease. We aimed to evaluate the feasibility of conducting a trial of an adapted home-based CR programme, 'The Healthy Brain Rehabilitation Manual', for patients following a TIA/minor stroke, participants' views on the intervention and, to identify the behaviour change techniques (BCTs) used.

Methods: Clinicians were asked to identify patients attending the Ulster Hospital, Belfast within 4 weeks of a first TIA or minor stroke. Those who agreed to participate underwent assessments of physical fitness, cardiovascular risk, quality of life and mental health, before random allocation to: Group (1) standard/usual care; (2) rehabilitation manual or (3) manual plus pedometer. All participants received telephone support at 1 and 4 weeks, reassessment at 6 weeks and an invitation to a focus group exploring views regarding the study. Two trained review authors independently assessed the manual to identify the BCTs used.

Results: Twenty-eight patients were invited to participate, with 15 (10 men, 5 women; 9 TIA, 6 minor stroke; mean age 69 years) consenting and completing the study. Mean time to enrolment from the TIA/stroke was 20.5 days. Participants completed all assessment measures except VO2max testing, which all declined. The manual and telephone contact were viewed positively, as credible sources of advice. Pedometers were valued highly, particularly for goal-setting. Overall, 36 individual BCTs were used, the commonest being centred around setting goals and planning as well as social support.

Conclusion: Recruitment and retention rates suggest that a trial to evaluate the effectiveness of a novel home-based CR programme, implemented within 4 weeks of a first TIA/minor stroke is feasible. The commonest BCTs used within the manual revolve around goals, planning and social support, in keeping with UK national guidelines. The findings from this feasibility work have been used to further refine the next stage of the intervention's development, a pilot study.

Trial registration: Identifier: NCT02712385 . This study was registered prospectively on 18/03/2016.

Keywords: Cardiac rehabilitation; Minor stroke; SPRITE; Secondary cardiovascular prevention; TIA; ‘The Healthy Brain Rehabilitation Manual’; ‘The Heart Manual’.

Conflict of interest statement

Ethics approval and consent to participate

Ethical approval granted for SPRITE - Stroke Prevention Rehabilitation Intervention Trial of Exercise - A Feasibility and Pilot Study through OREC-NI, REC reference: 15/NI/0001, 21/09/2015. Written informed consent was obtained from all participants.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Fig. 1
Fig. 1
Intervention logic model

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    1. Strong K, Mathers C, Bonita R. Preventing stroke: saving lives around the world. Lancet Neurol. 2007;6(2):182–187. doi: 10.1016/S1474-4422(07)70031-5. - DOI - PubMed
    1. Scarborough P, Peto V, Bhatnagar P, Kaur A, Leal J, Luengo-Fernandez R, et al. Stroke statistics. London: British Heart Foundation and Stroke Association; 2009. pp. P41–P48.
    1. Selvarajah JR, Smith CJ, Hulme S, et al. Prognosis in patients with transient ischaemic attack (TIA) and minor stroke attending TIA services in the North West of England: the NORTHSTAR study. J Neurol Neurosurg Psychiatry. 2008;79(1):38–43. doi: 10.1136/jnnp.2007.129163. - DOI - PubMed
    1. Hughes J, Kee F, O'Flaherty M, Critchley J, Cupples M, Capewell S, et al. Modelling coronary heart disease mortality in Northern Ireland between 1987 and 2007: broader lessons for prevention. Eur J Prev Cardiol. 2013;20(2):310–321. doi: 10.1177/2047487312441725. - DOI - PubMed
    1. American Association of Cardiovascular and Pulmonary Rehabilitation . Guidelines for cardiac rehabilitation and secondary prevention programs, book. 5. 2013. p. 1.

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