Exercise Has the Guts: How Physical Activity May Positively Modulate Gut Microbiota in Chronic and Immune-Based Diseases

Dig Liver Dis. 2018 Apr;50(4):331-341. doi: 10.1016/j.dld.2017.11.016. Epub 2017 Nov 28.

Abstract

Limited animal and human research findings suggests that exercise might have a beneficial role for health gut. Cardiorespiratory fitness correlates with health-associated gut parameters such as taxonomic diversity and richness. Physical exercise may augment intestinal microbial diversity through several mechanisms including promotion of an anti-inflammatory state. Disease-associated microbial functions were linked to distinct taxa in previous studies of familial type 1 diabetes mellitus (T1D). An integrated multi-approach in the study of T1D, including physical exercise, is advocated. The present review explores how exercise might modulate gut microbiota and microbiome characteristics in chronic and immune-based diseases, given the demonstrated relationship between gut function and human health.

Keywords: Exercise; Gut microbiota; Type 1 diabetes.

Publication types

  • Review

MeSH terms

  • Animals
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / microbiology*
  • Disease Models, Animal
  • Exercise / physiology*
  • Gastrointestinal Microbiome / physiology*
  • Gastrointestinal Tract / microbiology*
  • Gastrointestinal Tract / physiology*
  • Humans
  • Mice
  • Rats