Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2017 Dec;174(24):4543-4546.
doi: 10.1111/bph.14065.

WNT Signalling: Mechanisms and Therapeutic Opportunities

Affiliations
Free PMC article
Editorial

WNT Signalling: Mechanisms and Therapeutic Opportunities

Gunnar Schulte et al. Br J Pharmacol. .
Free PMC article

Abstract

This themed section of the British Journal of Pharmacology stems from the EMBO Conference: Wnt Meeting 2016 held from the 14th to 16th September 2016 in Brno, Czech Republic.

Linked articles: This article is part of a themed section on WNT Signalling: Mechanisms and Therapeutic Opportunities. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.24/issuetoc.

Figures

Figure 1
Figure 1
WNT signalling pathways. (A) The best known WNT pathway is the WNT/β‐catenin pathway. During the OFF state, the destruction complex consisting of Axin, APC and GSK‐3β phosphorylates β‐catenin and marks it for subsequent degradation via the ubiquitin proteasome pathway. WNTs activate the pathway via FZD and LDL receptor‐related protein 5/6 (LRP5/6) receptors. This leads to phosphorylation of LRP5/6 initiating the recruitment of the destruction complex and stopping its function. As a consequence, β‐catenin accumulates and triggers transcription via T‐cell factor/lymphoid enhancer‐binding factor (TCF/LEF) transcription factors. (B) WNTs can also activate pathways independent of β‐catenin. (1) The best known is the Wnt/planar cell polarity (PCP) pathway. Activation of the vertebrate PCP pathway is triggered by WNTs (typically Wnt5a or Wnt11) that interact with FZD and coreceptors (ROR1, ROR2, PTK7 or RYK) and via Dishvelled (DVL) and β‐arrestin to activate members of the Rho family of small GTPases. Coordinated activation of downstream effectors – JNK and ROCK – induces cytoskeletal rearrangements that in turn influence processes ranging from convergent extension movements to positioning of basal bodies or cilia. (2) WNTs were shown to induce the release of intracellular Ca2+ stores that can activate a multitude of Ca2+‐dependent effectors to modulate both transcription as well as actin cytoskeleton. This schematic overview does not cover all different pathways activated by WNTs. The figure was created by Jakub Harnoš and Igor Červenka.

Similar articles

See all similar articles

Cited by 1 article

Publication types

MeSH terms

Substances

Feedback