Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women

Anita J Valkama; Jelena M Meinilä; Saila B Koivusalo; Jaana Lindström; Kristiina Rönö; Aila E Tiitinen; Beata Stach-Lempinen; Hannu J Kautiainen; Heli Viljakainen; Sture Andersson; Johan G Eriksson

doi:10.1038/s41430-017-0010-0

Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women

Eur J Clin Nutr. 2018 Mar;72(3):460-463. doi: 10.1038/s41430-017-0010-0. Epub 2017 Nov 6.

Authors

Anita J Valkama^{1

2}, Jelena M Meinilä³, Saila B Koivusalo⁴, Jaana Lindström⁵, Kristiina Rönö⁴, Aila E Tiitinen⁴, Beata Stach-Lempinen⁶, Hannu J Kautiainen^{3

7}, Heli Viljakainen^{8

9}, Sture Andersson⁹, Johan G Eriksson^{3

8

5}

Affiliations

¹ Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland. anita.valkama@helsinki.fi.
² Folkhälsan Research Center, University of Helsinki, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland. anita.valkama@helsinki.fi.
³ Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland.
⁴ Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Sofianlehdonkatu 5A, P.O. Box 610, 00029, Helsinki, Finland.
⁵ Department of Chronic Disease Prevention, National Institute for Health and Welfare, Mannerheimintie 166, P.O. Box 30, 00271, Helsinki, Finland.
⁶ Department of Obstetrics and Gynecology, South Karelia Central Hospital, Valto Käkelän katu 3, 53130, Lappeenranta, Finland.
⁷ Department of General Practice and Primary Health Care, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, 70211, Kuopio, Finland.
⁸ Folkhälsan Research Center, University of Helsinki, Tukholmankatu 8 B, P.O. Box 20, 00014, Helsinki, Finland.
⁹ Children's Hospital, University of Helsinki and Helsinki University Hospital, Stenbäckinkatu 11, P.O. Box 281, 00029, Helsinki, Finland.

PMID: 29235559
DOI: 10.1038/s41430-017-0010-0

Abstract

Obesity increases the risk of low 25-hydroxyvitamin D (25(OH)D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH)D concentrations measured in the first (7-18 wk) and second (20-27 wk) trimesters of pregnancy is dependent on maternal BMI. The study was a prospective study of 219 women with BMI of ≥30 kg/m², a history of GDM, or both. The participants were stratified by first-trimester BMI: BMI of <25.0, 25.0-29.9, 30.0-34.9, and ≥35 kg/m². In the BMI group ≥35 kg/m², those who did not develop GDM during the follow-up showed higher increase in serum 25(OH)D concentrations compared with women who developed GDM (43.2 vs. 11.5%; P < 0.001). No associations between 25(OH)D concentrations and GDM were observed in other BMI groups. These findings give an important aspect of the role of maternal body size in the association between vitamin D and GDM in high-risk women.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Body Size / physiology*
Diabetes, Gestational / blood*
Diabetes, Gestational / epidemiology*
Female
Humans
Pregnancy
Prospective Studies
Vitamin D / analogs & derivatives*
Vitamin D / blood

Substances

Vitamin D
25-hydroxyvitamin D