Hereditary spastic paraplegia from 1880 to 2017: an historical review

Arq Neuropsiquiatr. 2017 Nov;75(11):813-818. doi: 10.1590/0004-282X20170160.


The authors have constructed a brief timeline of major clinical research related to hereditary spastic paraplegia (HSP). This timeline summarizes the evolution of HSP research, from the first clinical descriptions by Adolf von Strümpell in 1880 to the present day, with the transformation of these diseases into a rapidly-growing and heterogeneous group of neurogenetic diseases.

Publication types

  • Historical Article
  • Review

MeSH terms

  • History, 19th Century
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Spastic Paraplegia, Hereditary / history*