Toxicity of long-term use of proton pump inhibitors in children

Arch Dis Child. 2018 Jan;103(1):78-82. doi: 10.1136/archdischild-2017-314026.


Proton pump inhibitor (PPI) use is becoming increasingly common. Although the toxicity profiles of PPIs are not well understood particularly in children, PPIs have been associated with increased risks of gastrointestinal and respiratory tract infection, vitamin B12 deficiency, hypomagnesaemia, bone fractures, and rebound hyperacidity after discontinuation. Prescribers should take into account that PPI uses pose toxicity risks, which remain to be fully characterised in infants and children.

Keywords: adverse events; children; gastroesophageal reflux; proton pump inhibitors; safety.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Gastroesophageal Reflux / drug therapy*
  • Humans
  • Proton Pump Inhibitors / adverse effects*
  • Risk


  • Proton Pump Inhibitors