Plasmodium Peekaboo: PK4 Mediates Parasite Latency

Edward Rea; Anthony A Holder; Rita Tewari

doi:10.1016/j.chom.2017.11.011

Plasmodium Peekaboo: PK4 Mediates Parasite Latency

Cell Host Microbe. 2017 Dec 13;22(6):724-725. doi: 10.1016/j.chom.2017.11.011.

Authors

Edward Rea¹, Anthony A Holder², Rita Tewari³

Affiliations

¹ School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
² The Francis Crick Institute, London, UK.
³ School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK. Electronic address: rita.tewari@nottingham.ac.uk.

PMID: 29241036
DOI: 10.1016/j.chom.2017.11.011

Abstract

In this issue of Cell Host & Microbe, Zhang et al. (2017) show that translational repression through eIF2α phosphorylation mediated by PK4 kinase activity plays a key role in artemisinin resistance in recrudescent malaria infections. Targeting this druggable process could extend the lifespan of current frontline treatments.

Publication types

Comment

MeSH terms

Animals
Antimalarials
Drug Resistance / drug effects
Eukaryotic Initiation Factor-2
Malaria
Malaria, Falciparum
Parasites*
Phosphorylation
Plasmodium falciparum
Plasmodium*

Substances

Antimalarials
Eukaryotic Initiation Factor-2

Abstract

Publication types

MeSH terms

Substances

Grants and funding