Measles virus editing provides an additional cysteine-rich protein

Cell. 1989 Mar 10;56(5):759-64. doi: 10.1016/0092-8674(89)90679-x.

Abstract

The measles virus (MV) phosphoprotein (P) gene encodes two known proteins, P (Mr approximately 70,000), involved in viral transcription, and, in a different reading frame, C (Mr approximately 20,000). By a combination of cDNA cloning, cDNA and RNA sequencing, and in vitro translation, we demonstrate here that the MV P gene also expresses a third product (Mr approximately 46,000) containing the amino-terminal region of P but a different, cysteine-rich carboxy-terminal motif. This third protein is translated from mRNAs in which one G residue has been inserted after three genomically encoded Gs, a modification found in about 50% of the P mRNAs. A smaller fraction of transcripts contain several additional G residues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cysteine
  • Gene Expression Regulation
  • Genes, Viral
  • Measles virus / genetics*
  • RNA, Viral / genetics*
  • Viral Proteins / genetics*

Substances

  • RNA, Viral
  • Viral Proteins
  • Cysteine