Gas6 as a predictor of esophageal varices in patients affected by hepatitis C virus related-chronic liver disease

Biomark Med. 2018 Jan;12(1):27-34. doi: 10.2217/bmm-2017-0171. Epub 2017 Dec 15.


Aim: Plasma Gas6 was tested as an alternative to Baveno VI criteria (liver stiffness <20 kPa and platelet count >150 × 109/l) in an endoscopy-sparing strategy.

Methods: A total of 160 patients with chronic hepatitis C and advanced fibrosis/cirrhosis underwent, on the same occasion, liver elastography, upper endoscopy, a platelet count and serum Gas6 measurement.

Results: A total of 74/160 (46%) patients had esophageal varices, that were small (diameter <5 mm) in 57/160 (34%) and large in 17/160 (11%) cases. A total of 34/160 (21%) patients satisfied Baveno VI criteria, according to which screening for esophageal varices could have been omitted; 1/34 had large varices (sensitivity 94%). A plasma Gas6 value <45 ng/ml, detected in 34/160 (21%) patients, was also 94% sensitive.

Conclusion: Plasma Gas6 might represent a feasible alternative to Baveno VI criteria when transient elastography is unavailable/unsuccessful.

Keywords: Gas6; cirrhosis; esophageal varices.

MeSH terms

  • Aged
  • Esophageal and Gastric Varices / blood*
  • Esophageal and Gastric Varices / virology
  • Female
  • Hepacivirus / pathogenicity*
  • Humans
  • Intercellular Signaling Peptides and Proteins / blood*
  • Liver / virology
  • Liver Diseases / blood*
  • Liver Diseases / virology
  • Male
  • Middle Aged


  • Intercellular Signaling Peptides and Proteins
  • growth arrest-specific protein 6