Another One (of the "Undruggable" Targets) Bites the Dust: Discovery of a Potent and Selective Inhibitor of the Histone Acetyl Transferase p300/CBP

Biochemistry. 2018 Feb 13;57(6):899-900. doi: 10.1021/acs.biochem.7b01179. Epub 2017 Dec 15.
No abstract available

MeSH terms

  • Animals
  • Binding Sites / drug effects
  • Coenzyme A / metabolism
  • Drug Discovery
  • Heterocyclic Compounds, 4 or More Rings / chemistry
  • Heterocyclic Compounds, 4 or More Rings / pharmacology*
  • Humans
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / pharmacology*
  • p300-CBP Transcription Factors / antagonists & inhibitors*
  • p300-CBP Transcription Factors / metabolism

Substances

  • A-485 compound
  • Heterocyclic Compounds, 4 or More Rings
  • Small Molecule Libraries
  • p300-CBP Transcription Factors
  • Coenzyme A