Another One (of the "Undruggable" Targets) Bites the Dust: Discovery of a Potent and Selective Inhibitor of the Histone Acetyl Transferase p300/CBP

Biochemistry. 2018 Feb 13;57(6):899-900. doi: 10.1021/acs.biochem.7b01179. Epub 2017 Dec 15.

Author

Thomas Kodadek¹

Affiliation

¹ Department of Chemistry, The Scripps Research Institute , 130 Scripps Way, Jupiter, Florida 33458, United States.

PMID: 29244478
DOI: 10.1021/acs.biochem.7b01179

No abstract available

MeSH terms

Animals
Binding Sites / drug effects
Coenzyme A / metabolism
Drug Discovery
Heterocyclic Compounds, 4 or More Rings / chemistry
Heterocyclic Compounds, 4 or More Rings / pharmacology*
Humans
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*
p300-CBP Transcription Factors / antagonists & inhibitors*
p300-CBP Transcription Factors / metabolism

Substances

A-485 compound
Heterocyclic Compounds, 4 or More Rings
Small Molecule Libraries
p300-CBP Transcription Factors
Coenzyme A