GAPs in early life facilitate immune tolerance

Sci Immunol. 2017 Dec 15;2(18):eaar2465. doi: 10.1126/sciimmunol.aar2465.

Abstract

Goblet cells deliver microbial antigens to generate regulatory T cells before and during weaning to induce long-term tolerance to symbionts.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology*
  • Goblet Cells / immunology*
  • Humans
  • Immune Tolerance / immunology*
  • Symbiosis / immunology
  • T-Lymphocytes, Regulatory / immunology*

Substances

  • Antigens, Bacterial