Immune senescence and biomarkers profile of Bambuí aged population-based cohort

Exp Gerontol. 2018 Mar;103:47-56. doi: 10.1016/j.exger.2017.12.006. Epub 2017 Dec 14.


During immunosenescence many proinflammatory markers such as cytokines and chemokines are increased. This process called by Franceschi and colleagues as inflammaging is associated with chronic inflammation and the ethiology and pathophysiolgy of many ageing diseases as Alzheimer's and atherosclerosis. The knowledge of immune profile during ageing may provide some interventions that would improve the immune function in elderly and quality of life for old people. However, the identification of a group of potential biomarkers to monitor the ageing process is very difficult. In addition, most of the evidence evaluating immune biomarkers profile is based on data from older Caucasian adults. To our knowledge, no previous Latin American old population-based cohort has evaluated immunological parameters along the ageing process. The present work evaluated CXCL8, CXCL9, CXCL10, CCL2, CCL5, IL-1, IL-6, IL-12, TNF and IL-10 serum levels in 1494 older adults aged 60 to 95 from a population based ageing cohort in Brazil. Our data suggest that there is an increased positive predicted probability of participants to be a high producer of IL-6, CXCL8 and CXCL9. Moreover, results did not differ between men and women, except for CXCL10 that increased only in men. Results were not different in the adjusted model by many potential confounders, including African genomic ancestry. Together, these findings add novel insights about the immunologic aspects of ageing supported by a large population-based cohort study that provides evidences that corroborate with the inflammaging proposal and subsidize the establishment of biomarkers for monitoring the health status of aged population.

Keywords: Ageing; Biomarkers; CXCL8; CXCL9; Gender; IL-6; Population-based cohort.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / blood*
  • Biomarkers / blood*
  • Brazil
  • Chemokine CXCL10 / blood
  • Chemokine CXCL9 / blood
  • Cohort Studies
  • Female
  • Humans
  • Immunosenescence*
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Logistic Models
  • Male
  • Middle Aged
  • Sex Factors


  • Biomarkers
  • CXCL10 protein, human
  • CXCL8 protein, human
  • CXCL9 protein, human
  • Chemokine CXCL10
  • Chemokine CXCL9
  • IL6 protein, human
  • Interleukin-6
  • Interleukin-8