H2S and polysulfide metabolism: Conventional and unconventional pathways

Abstract

It is now well established that hydrogen sulfide (H₂S) is an effector of a wide variety of physiological processes. It is also clear that many of the effects of H₂S are mediated through reactions with cysteine sulfur on regulatory proteins and most of these are not mediated directly by H₂S but require prior oxidation of H₂S and the formation of per- and polysulfides (H₂S_n, n = 2-8). Attendant with understanding the regulatory functions of H₂S and H₂S_n is an appreciation of the mechanisms that control, i.e., both increase and decrease, their production and catabolism. Although a number of standard "conventional" pathways have been described and well characterized, novel "unconventional" pathways are continuously being identified. This review summarizes our current knowledge of both the conventional and unconventional.

Keywords: Mitochondria; Persulfide; Sulfur metabolism; Sulfur signaling.