Kratom use and mental health: A systematic review

Drug Alcohol Depend. 2018 Feb 1:183:134-140. doi: 10.1016/j.drugalcdep.2017.10.012. Epub 2017 Dec 7.


Background: Kratom (Mitragyna speciosa) is a psychoactive plant native to Southeastern Asia that is receiving increased international attention as a potential therapeutic agent. While much of the limited scientific research on kratom is focused on its analgesic potential, kratom use also has important risks and benefits in the domain of mental health.

Methods: We conducted a comprehensive systematic review of all studies on kratom use and mental health published between January 1960 and July 2017.

Results: Findings indicate kratom's potential as a harm reduction tool, most notably as a substitute for opioids among people who are addicted. Kratom also enhances mood and relieves anxiety among many users. For many, kratom's negative mental health effects - primarily withdrawal symptoms - appear to be mild relative to those of opioids. For some users, however, withdrawal is highly uncomfortable and maintaining abstinence becomes difficult.

Conclusion: Results inform clinicians working in the mental health and substance use fields, policy-makers, and researchers about the mental health effects of this plant.

Keywords: Harm reduction; Kratom; Mitragyna speciosa; Substitution.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Anxiety Disorders / drug therapy
  • Anxiety Disorders / epidemiology
  • Anxiety Disorders / psychology
  • Harm Reduction
  • Humans
  • Mental Health* / trends
  • Mitragyna*
  • Retrospective Studies
  • Secologanin Tryptamine Alkaloids / administration & dosage*
  • Secologanin Tryptamine Alkaloids / adverse effects
  • Substance Withdrawal Syndrome / drug therapy
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / psychology*


  • Secologanin Tryptamine Alkaloids
  • mitragynine