Uniform magnetic targeting of magnetic particles attracted by a new ferromagnetic biological patch

Bioelectromagnetics. 2018 Feb;39(2):98-107. doi: 10.1002/bem.22105. Epub 2017 Dec 18.


A new non-toxic ferromagnetic biological patch (MBP) was designed in this paper. The MBP consisted of two external layers that were made of transparent silicone, and an internal layer that was made of a mixture of pure iron powder and silicon rubber. Finite-element analysis showed that the local inhomogeneous magnetic field (MF) around the MBP was generated when MBP was placed in a uniform MF. The local MF near the MBP varied with the uniform MF and shape of the MBP. Therefore, not only could the accumulation of paramagnetic particles be adjusted by controlling the strength of the uniform MF, but also the distribution of the paramagnetic particles could be improved with the different shape of the MBP. The relationship of the accumulation of paramagnetic particles or cells, magnetic flux density, and fluid velocity were studied through in vitro experiments and theoretical considerations. The accumulation of paramagnetic particles first increased with increment in the magnetic flux density of the uniform MF. But when the magnetic flux density of the uniform MF exceeded a specific value, the magnetic flux density of the MBP reached saturation, causing the accumulation of paramagnetic particles to fall. In addition, the adsorption morphology of magnetic particles or cells could be improved and the uniform distribution of magnetic particles could be achieved by changing the shape of the MBP. Also, MBP may be used as a new implant to attract magnetic drug carrier particles in magnetic drug targeting. Bioelectromagnetics. 39:98-107, 2018. © 2017 Wiley Periodicals, Inc.

Keywords: adsorption morphology; capture efficiency; finite-element analysis; mesenchymal stem cells.

MeSH terms

  • Adsorption
  • Animals
  • Drug Delivery Systems / methods*
  • Magnetic Fields*
  • Magnets* / chemistry
  • Male
  • Mesenchymal Stem Cells / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Silicon Dioxide / chemistry


  • Silicon Dioxide