Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis

FEBS Lett. 2018 Jan;592(2):199-208. doi: 10.1002/1873-3468.12941. Epub 2018 Jan 9.


Viperin is a radical SAM enzyme that possesses antiviral properties against a broad range of enveloped viruses. Here, we describe the activity of human viperin with two molecules of the mevalonate pathway, geranyl pyrophosphate, and farnesyl pyrophosphate, involved in cholesterol biosynthesis. We postulate that the radical modification of these two molecules by viperin might lead to defects in cholesterol synthesis, thereby affecting the composition of lipid rafts and subsequent enveloped virus budding.

Keywords: antiviral activity; innate immunity; radical SAM; viperin.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • Cholesterol / biosynthesis
  • Humans
  • Models, Molecular
  • Molecular Docking Simulation
  • Oxidoreductases Acting on CH-CH Group Donors
  • Polyisoprenyl Phosphates / chemistry
  • Polyisoprenyl Phosphates / metabolism*
  • Proteins / chemistry
  • Proteins / metabolism*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / metabolism*
  • Substrate Specificity
  • Virus Release


  • Polyisoprenyl Phosphates
  • Proteins
  • Sesquiterpenes
  • geranyl pyrophosphate
  • farnesyl pyrophosphate
  • Cholesterol
  • Oxidoreductases Acting on CH-CH Group Donors
  • RSAD2 protein, human