Artificial scotoma estimation based on population receptive field mapping

Neuroimage. 2018 Apr 1:169:342-351. doi: 10.1016/j.neuroimage.2017.12.010. Epub 2017 Dec 15.

Abstract

Population receptive field (pRF) mapping based on functional magnetic resonance imaging (fMRI) is an ideal method for obtaining detailed retinotopic information. One particularly promising application of pRF mapping is the estimation and quantification of visual field effects, for example scotomata in patients suffering from macular dysfunction or degeneration (MD) or hemianopic defects in patients with intracranial dysfunction. However, pRF mapping performance is influenced by a number of factors including spatial and temporal resolution, distribution of dural venous sinuses and patient performance. This study addresses the ability of current pRF methodology to assess the size of simulated scotomata in healthy individuals. The data demonstrate that central scotomata down to a radius of 2.35° (4.7° diameter) visual angle can be reliably estimated in single subjects using high spatial resolution protocols and multi-channel receive array coils.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping / methods*
  • Female
  • Healthy Volunteers
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Pattern Recognition, Visual / physiology*
  • Perceptual Masking / physiology*
  • Scotoma / diagnostic imaging
  • Visual Cortex / diagnostic imaging*
  • Visual Fields / physiology*
  • Young Adult