Complete hazard ranking to analyze right-censored data: An ALS survival study

PLoS Comput Biol. 2017 Dec 18;13(12):e1005887. doi: 10.1371/journal.pcbi.1005887. eCollection 2017 Dec.

Abstract

Survival analysis represents an important outcome measure in clinical research and clinical trials; further, survival ranking may offer additional advantages in clinical trials. In this study, we developed GuanRank, a non-parametric ranking-based technique to transform patients' survival data into a linear space of hazard ranks. The transformation enables the utilization of machine learning base-learners including Gaussian process regression, Lasso, and random forest on survival data. The method was submitted to the DREAM Amyotrophic Lateral Sclerosis (ALS) Stratification Challenge. Ranked first place, the model gave more accurate ranking predictions on the PRO-ACT ALS dataset in comparison to Cox proportional hazard model. By utilizing right-censored data in its training process, the method demonstrated its state-of-the-art predictive power in ALS survival ranking. Its feature selection identified multiple important factors, some of which conflicts with previous studies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Amyotrophic Lateral Sclerosis / mortality*
  • Computational Biology
  • Databases, Factual
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Machine Learning
  • Male
  • Normal Distribution
  • Proportional Hazards Models
  • Regression Analysis
  • Statistics, Nonparametric
  • Survival Analysis*