Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells

Semin Immunol. 2018 Feb;35:19-28. doi: 10.1016/j.smim.2017.12.004. Epub 2017 Dec 15.

Abstract

Neutrophils and polymorphonucler myeloid-derived suppressor cells (PMN-MDSC) share origin and many morphological and phenotypic features. However, they have different biological role. Neutrophils are one of the major mechanisms of protection against invading pathogens, whereas PMN-MDSC have immune suppressive activity and restrict immune responses in cancer, chronic infectious disease, trauma, sepsis, and many other pathological conditions. Although in healthy adult individuals, PMN-MDSC are not or barely detectable, in patients with cancer and many other diseases they accumulate at various degree and co-exist with neutrophils. Recent advances allow for better distinction of these cells and better understanding of their biological role. Accumulating evidence indicates PMN-MDSC as pathologically activated neutrophils, with important role in regulation of immune responses. In this review, we provide an overview on the definition and characterization of PMN-MDSC and neutrophils, their pathological significance in a variety of diseases, and their interaction with other stromal components.

Keywords: Cancer; Fibroblasts; Infectious diseases; Myeloid-derived suppressor cells; Neutrophils.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Communication
  • Communicable Diseases / immunology*
  • Humans
  • Immunity, Cellular
  • Immunomodulation
  • Myeloid-Derived Suppressor Cells / immunology*
  • Neoplasms / immunology*
  • Neutrophils / immunology*
  • Stromal Cells / immunology*