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. 1989 Feb;42(2):230-5.
doi: 10.7164/antibiotics.42.230.

Metabolic Products of Microorganisms. 252. Isolation of New Nikkomycins From Streptomyces Tendae

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Metabolic Products of Microorganisms. 252. Isolation of New Nikkomycins From Streptomyces Tendae

H Decker et al. J Antibiot (Tokyo). .
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Abstract

Two new nikkomycins were isolated from the culture broth of Streptomyces tendae Tü 901/PF 53+-3. The new compounds are the dipeptide nikkomycin pseudo-Z (psi Z) and tripeptide nikkomycin pseudo-J (psi J), which are analogues to nikkomycins Z and J. Nikkomycins pseudo-Z and pseudo-J have a C-glycosidic linkage between uracil and 5-amino-5-deoxy-D-allo-furanuronic acid, which is comparable to the C-glycosidic bond in pseudouridine. The new Cc-nucleoside nikkomycins exhibit a lower biological activity than the CN-nucleoside nikkomycins.

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