HIV-associated disruption of lung cytokine networks is incompletely restored in asymptomatic HIV-infected Malawian adults on antiretroviral therapy

ERJ Open Res. 2017 Dec 14;3(4):00097-2017. doi: 10.1183/23120541.00097-2017. eCollection 2017 Oct.

Kondwani C Jambo^{1

2

3}, Dumizulu L Tembo^{4

3}, Arox W Kamng'ona^{1

5}, Patrick Musicha^{1

6}, Dominic H Banda¹, Anstead M Kankwatira¹, Rose D Malamba¹, Theresa J Allain⁷, Robert S Heyderman^{1

8}, David G Russell⁴, Henry C Mwandumba^{1

2

7}

¹ Malawi-Liverpool-Wellcome Trust Clinical Research Programme, University of Malawi College of Medicine, Blantyre, Malawi.
² Dept of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.
³ These authors contributed equally.
⁴ Dept of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
⁵ Dept of Biomedical Sciences, University of Malawi, College of Medicine, Blantyre, Malawi.
⁶ Dept of Pathology, University of Malawi, College of Medicine, Blantyre, Malawi.
⁷ Dept of Medicine, University of Malawi, College of Medicine, Blantyre, Malawi.
⁸ Division of Infection and Immunity, University College London, London, UK.

Abstract

Disruption of lung cytokine networks during chronic HIV infection is incompletely restored in individuals on antiretroviral therapy.