Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants

Wei Li; Shannon L Risacher; Sujuan Gao; Stephen L Boehm 2nd; Jeffrey S Elmendorf; Andrew J Saykin

doi:10.1016/j.dadm.2017.11.002

Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid β1-42 in Alzheimer's Disease Neuroimaging Initiative participants

Alzheimers Dement (Amst). 2017 Nov 23:10:94-98. doi: 10.1016/j.dadm.2017.11.002. eCollection 2018.

Authors

Wei Li¹, Shannon L Risacher², Sujuan Gao³, Stephen L Boehm 2nd⁴, Jeffrey S Elmendorf^{5

6}, Andrew J Saykin²

Affiliations

¹ Department of Clinical and Diagnostic Sciences, Physician Assistant Studies, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.
² Department of Radiology and Imaging Sciences, Center for Neuroimaging, Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA.
³ Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, USA.
⁴ Department of Psychology, School of Science, Indiana University-Purdue University Indianapolis, Indianapolis, IN, USA.
⁵ Department of Cellular and Integrative Physiology, Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.
⁶ Department of Biochemistry and Molecular Biology, Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's disease. Cerebrospinal fluid (CSF) amyloid β (Aβ) 1-42 is an important Alzheimer's disease biomarker. However, it is inconclusive on how T2DM is related to CSF Aβ1-42.

Methods: Participants with T2DM were selected from the Alzheimer's Disease Neuroimaging Initiative by searching keywords from the medical history database. A two-way analysis of covariance model was used to analyze how T2DM associates with CSF Aβ1-42 or cerebral cortical Aβ.

Results: CSF Aβ1-42 was higher in the T2DM group than the nondiabetic group. The inverse relation between CSF Aβ1-42 and cerebral cortical Aβ was independent of T2DM status. Participants with T2DM had a lower cerebral cortical Aβ in anterior cingulate, precuneus, and temporal lobe than controls.

Discussion: T2DM is positively associated with CSF Aβ1-42 but negatively with cerebral cortical Aβ. The decreased cerebral cortical Aβ associated with T2DM is preferentially located in certain brain regions.

Keywords: Alzheimer's disease; Amyloid β; Aβ1-42; Cerebrospinal fluid (CSF); Type 2 diabetes mellitus.

Abstract

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