Chronic lung disorders, such as pulmonary artery hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma and neonatal bronchopulmonary dysplasia (BPD), are characterized by airway and/or vascular remodeling. Despite differences in the pathology, reactive oxygen species (ROS) have been highlighted as a critical contributor to the initiation and development of airway and vascular remodeling. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (Nox) appear to play a pivotal role in lung signaling, leading to marked changes in pulmonary airway and vascular cell phenotypes, including proliferation, hypertrophy and apoptosis. In this review, we summarized the current literature regarding the role of Nox in the airway and vascular remodeling.
Keywords: BPD; COPD; NADPH oxidase; PAH; asthma; remodeling.
Conflict of interest statement
The authors declare no conflict of interest.
Nicotinamide Adenine Dinucleotide Phosphate Oxidase-Mediated Redox Signaling and Vascular Remodeling by 16α-Hydroxyestrone in Human Pulmonary Artery Cells: Implications in Pulmonary Arterial HypertensionKY Hood et al. Hypertension 68 (3), 796-808. PMID 27402919.Estrogen and oxidative stress have been implicated in pulmonary arterial hypertension (PAH). Mechanisms linking these systems are elusive. We hypothesized that estrogen m …
NOX4 Expression and Distal Arteriolar Remodeling Correlate With Pulmonary Hypertension in COPDX Guo et al. BMC Pulm Med 18 (1), 111. PMID 29986678.These results suggest that the NOX4-derived ROS production may play a key role in the development of PH in COPD by promoting distal pulmonary vascular remodeling.
Deficiency of NOX1/nicotinamide Adenine Dinucleotide Phosphate, Reduced Form Oxidase Leads to Pulmonary Vascular RemodelingK Iwata et al. Arterioscler Thromb Vasc Biol 34 (1), 110-9. PMID 24233492.These findings suggest a critical role for NOX1 in cellular apoptosis by regulating Kv1.5 and intracellular potassium levels. Because dysfunction of Kv1.5 is among the fe …
Reactive Oxygen and Nitrogen Species in the Development of Pulmonary HypertensionDJR Fulton et al. Antioxidants (Basel) 6 (3). PMID 28684719. - ReviewPulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature that involves the loss of endothelial function together with inappropriate smooth m …
Composition and Functions of Vascular Nicotinamide Adenine Dinucleotide Phosphate OxidasesRP Brandes et al. Trends Cardiovasc Med 18 (1), 15-9. PMID 18206804. - ReviewNicotinamide adenine dinucleotide phosphate (NADPH) oxidases are important sources of reactive oxygen species (ROS) and are expressed in at least three different homologu …
Cited by 4 PubMed Central articles
Severe but Not Moderate Hyperoxia of Newborn Mice Causes an Emphysematous Lung Phenotype in Adulthood Without Persisting Oxidative Stress and InflammationA Kindermann et al. BMC Pulm Med 19 (1), 245. PMID 31842840.Severe but not moderate neonatal hyperoxia causes emphysematous lungs without persisting oxidative stress and inflammation in adulthood. As the existing fragmentation of …
Dried Yeast Extracts Curtails Pulmonary Oxidative Stress, Inflammation and Tissue Destruction in a Model of Experimental EmphysemaYH Kim et al. Antioxidants (Basel) 8 (9). PMID 31480536.Pulmonary emphysema is characterized by a loss of alveolar integrity due to prolonged cigarette smoking and inhaled irritants. Dried yeast extracts (YE) are employed as f …
Oxygen Toxicity in the Neonate: Thinking Beyond the BalanceTE Tipple et al. Clin Perinatol 46 (3), 435-447. PMID 31345539. - ReviewFetal development occurs in a relatively hypoxemic environment, and birth represents significant oxidative stress. Premature infants are disadvantaged by a lack of matern …
Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension DevelopmentO Rafikova et al. Antioxid Redox Signal 31 (13), 933-953. PMID 31169021.Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature characterized by the proliferation of all vascular wall …