Toxic effects of permethrin on Pseudorasbora parva

J Environ Biol. 2016 Nov;37(6):1247-53.

Abstract

The present study deals with acute toxicity and hematological, histopathological and genotoxical effects of permethrin, a synthetic pyrethroid, on Pseudorasbora parva. Acute toxicity of 96-hrs LC50 value was found to be 88.25 (84.60-92.63) μgl-1. Sublethal dose was taken as 8.82 μgl-1 (the 1/10 of the LC50 value) in bio-experiments. Micronucleus changes in blood erythrocyte and hemotocyte level in P. parva exposed to sub-lethal concentration were investigated. Difference between nucleolus abnormalities in the experimental and control group was found to be statistically significant (t-test). Micronucleus frequency was found to be 8.26. The hematocrit level in control and experimental groups were found to be 24.43% and 14.673%. No pathological symptoms were observed in the muscle of P. parva exposed to sublethal dose for 96 hrs. Pathological symptoms observed after 96 hours from permethrin administration in other organs were: Fusion, Telangiectasis, epithelial lifting and hyperemia in gills; hydropic degeneration, lipid degeneration and passive hyperemia in liver and enlargement of cavum glomeruli and Bowman space in kidneys and hemorrhage, edema and hyperemia in brain, respectively.

Keywords: Pseudorasbora parva; Permethrin; Genotoxicity; Micronucleus test; LC50 value.

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / pathology
  • Cyprinidae*
  • Gills / drug effects
  • Gills / pathology
  • Insecticides / toxicity*
  • Introduced Species
  • Kidney / drug effects
  • Kidney / pathology
  • Permethrin / toxicity*
  • Water Pollutants, Chemical / toxicity*

Substances

  • Insecticides
  • Water Pollutants, Chemical
  • Permethrin