Cardiac amyloidosis: An update on diagnosis and treatment

Cleve Clin J Med. 2017 Dec;84(12 Suppl 3):12-26. doi: 10.3949/ccjm.84.s3.02.


Cardiac amyloidosis (CA), once thought to be a rare disease, is increasingly recognized due to enhanced clinical awareness and better diagnostic imaging. CA is becoming of heightened interest to the cardiology community given more effective treatment strategies for light chain amyloidosis (AL), as well as emerging therapies for transthyretin amyloidosis (ATTR). Furthermore, reversing amyloid deposition in affected organs using monoclonal antibodies is actively being tested in clinical trials. A high index of suspicion and a systematic approach to the diagnosis of CA can lead to referral to a center of expertise for timely treatment.

Publication types

  • Review

MeSH terms

  • Amyloid Neuropathies, Familial / diagnosis*
  • Amyloid Neuropathies, Familial / therapy*
  • Heart Diseases / diagnosis*
  • Heart Diseases / therapy*
  • Humans

Supplementary concepts

  • Amyloidosis, Hereditary, Transthyretin-Related