Chemical constituents and anti-inflammatory activity of leaf essential oil of Nigerian grown Chenopodium album L

L A Usman; A A Hamid; N O Muhammad; N O Olawore; T I Edewor; B K Saliu

Chemical constituents and anti-inflammatory activity of leaf essential oil of Nigerian grown Chenopodium album L

EXCLI J. 2010 Dec 7:9:181-186. eCollection 2010.

Authors

L A Usman¹, A A Hamid¹, N O Muhammad², N O Olawore³, T I Edewor³, B K Saliu⁴

Affiliations

¹ Department of Chemistry, University of Ilorin, Ilorin, Nigeria.
² Department of Biochemistry, University of Ilorin, Ilorin, Nigeria.
³ Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
⁴ Department of Microbiology, University of Ilorin, Ilorin, Nigeria.

PMID: 29259536
PMCID: PMC5698885

Abstract

Hydrodistilled leaves of Chenopodiumalbum yielded 0.64 % v/w of essential oil. GC and GC/MS analyses of the oil revealed that the bulk of the oil was constituted by aromatic compounds (60.1 %). The abundant constituents of the oil were: p- cymene (40.9 %), ascaridole (15.5 %), pinane-2-ol (9.9 %), α-pinene (7.0 %), β-pinene (6.2 %) and α-terpineol (6.2 %). The oil displayed strong anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA) - induced ear edema in mice.

Keywords: Chenopodium album; alpha-terpineol; anti-inflammatory; ascaridole; chenopodiaceae; p-cymene; pinane-2-ol.