In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan.


Nitrofurantoin is an antibiotic medication that is used for the treatment of uncomplicated lower urinary tract infections. It is effective against most gram-positive and gram-negative organisms. Nitrofurantoin’s primary use has remained in treating and prophylaxis of urinary tract infections. Nitrofurantoin is advantageous as it concentrates in the lower urinary tract while maintaining a low serum concentration and does not significantly affect bowel flora. This activity outlines the indications, mechanism of action, methods of administration, important adverse effects, contraindications, monitoring, and toxicity of nitrofurantoin, so providers can direct patient therapy successfully in instances where nitrofurantoin provides a benefit to patient care.

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  • Study Guide