Shape analysis of the basioccipital bone in Pax7-deficient mice

Sci Rep. 2017 Dec 20;7(1):17955. doi: 10.1038/s41598-017-18199-9.


We compared the cranial base of newborn Pax7-deficient and wildtype mice using a computational shape modeling technology called particle-based modeling (PBM). We found systematic differences in the morphology of the basiooccipital bone, including a broadening of the basioccipital bone and an antero-inferior inflection of its posterior edge in the Pax7-deficient mice. We show that the Pax7 cell lineage contributes to the basioccipital bone and that the location of the Pax7 lineage correlates with the morphology most effected by Pax7 deficiency. Our results suggest that the Pax7-deficient mouse may be a suitable model for investigating the genetic control of the location and orientation of the foramen magnum, and changes in the breadth of the basioccipital.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn / anatomy & histology
  • Heterozygote
  • Homozygote
  • Mice
  • Mice, Inbred C57BL
  • Occipital Bone / anatomy & histology*
  • Occipital Bone / diagnostic imaging
  • Occipital Bone / embryology
  • Occipital Bone / growth & development
  • PAX7 Transcription Factor / deficiency*
  • PAX7 Transcription Factor / physiology
  • Skull Base / anatomy & histology
  • Skull Base / diagnostic imaging
  • X-Ray Microtomography


  • PAX7 Transcription Factor
  • Pax7 protein, mouse