Familial vestibulocerebellar dysfunction: a new syndrome?

J Neurol Sci. 1989 Feb;89(2-3):149-55. doi: 10.1016/0022-510x(89)90016-6.


Three members of a single family with the symptom of "motion sickness" showed rebound nystagmus, saccadic pursuit eye movements, defective optokinetic slow phase velocity and lack of fixation suppression of vestibularly induced nystagmus. One of them showed vestibular hyperreactivity and a gradual build-up of the optokinetic response. In absence of other abnormalities, these findings can be localized to the vestibulocerebellum (flocculo-nodular lobe).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cerebellar Diseases / genetics*
  • Cerebellar Diseases / physiopathology
  • Child
  • Female
  • Humans
  • Nystagmus, Pathologic / etiology
  • Nystagmus, Pathologic / physiopathology
  • Reflex, Vestibulo-Ocular
  • Syndrome
  • Vestibular Nerve / physiopathology*