Bone quality changes associated with aging and disease: a review
- PMID: 29265417
- PMCID: PMC5774017
- DOI: 10.1111/nyas.13572
Bone quality changes associated with aging and disease: a review
Erratum in
-
Corrigendum for Ann. N.Y. Acad. Sci. 2017. Vol. 1410: 93-106.Ann N Y Acad Sci. 2018 Aug;1425(1):96. doi: 10.1111/nyas.13937. Ann N Y Acad Sci. 2018. PMID: 31883347 No abstract available.
Abstract
Bone quality encompasses all the characteristics of bone that, in addition to density, contribute to its resistance to fracture. In this review, we consider changes in architecture, porosity, and composition, including collagen structure, mineral composition, and crystal size. These factors all are known to vary with tissue and animal ages, and health status. Bone morphology and presence of microcracks, which also contribute to bone quality, will not be discussed in this review. Correlations with mechanical performance for collagen cross-linking, crystallinity, and carbonate content are contrasted with mineral content. Age-dependent changes in humans and rodents are discussed in relation to rodent models of disease. Examples are osteoporosis, osteomalacia, osteogenesis imperfecta (OI), and osteopetrosis in both humans and animal models. Each of these conditions, along with aging, is associated with increased fracture risk for distinct reasons.
Keywords: FTIR imaging; bone composition; microCT; osteogenesis imperfecta; osteoporosis.
© 2017 New York Academy of Sciences.
Figures
Similar articles
-
Are Changes in Composition in Response to Treatment of a Mouse Model of Osteogenesis Imperfecta Sex-dependent?Clin Orthop Relat Res. 2015 Aug;473(8):2587-98. doi: 10.1007/s11999-015-4268-z. Clin Orthop Relat Res. 2015. PMID: 25903941 Free PMC article.
-
Effect of anti-sclerostin therapy and osteogenesis imperfecta on tissue-level properties in growing and adult mice while controlling for tissue age.Bone. 2016 Mar;84:222-229. doi: 10.1016/j.bone.2016.01.001. Epub 2016 Jan 6. Bone. 2016. PMID: 26769006 Free PMC article.
-
Altered distributions of bone tissue mineral and collagen properties in women with fragility fractures.Bone. 2016 Mar;84:237-244. doi: 10.1016/j.bone.2016.01.012. Epub 2016 Jan 15. Bone. 2016. PMID: 26780445
-
Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease.Endocr Rev. 2007 Apr;28(2):151-64. doi: 10.1210/er.2006-0029. Epub 2006 Dec 19. Endocr Rev. 2007. PMID: 17200084 Review.
-
Mortality and morbidity in patients with osteogenesis imperfecta in Denmark.Dan Med J. 2018 Apr;65(4):B5454. Dan Med J. 2018. PMID: 29619932 Review.
Cited by
-
DXA evaluation of bone fragility 2 years after bariatric surgery in patients with obesity.Bone Rep. 2024 Jun 22;22:101782. doi: 10.1016/j.bonr.2024.101782. eCollection 2024 Sep. Bone Rep. 2024. PMID: 39035627 Free PMC article.
-
NFATc1 Is Required for Vitamin D- and Phosphate-Mediated Regulation of Osteocyte Lacuno-Canalicular Remodeling.Endocrinology. 2024 Jul 1;165(8):bqae087. doi: 10.1210/endocr/bqae087. Endocrinology. 2024. PMID: 39024412
-
Discrimination of ivory from extant and extinct elephant species using Raman spectroscopy: A potential non-destructive technique for combating illegal wildlife trade.PLoS One. 2024 Apr 24;19(4):e0299689. doi: 10.1371/journal.pone.0299689. eCollection 2024. PLoS One. 2024. PMID: 38656936 Free PMC article.
-
Influence of helical pitch and gantry rotation time on image quality and file size in ultrahigh-resolution photon-counting detector CT.Sci Rep. 2024 Apr 23;14(1):9358. doi: 10.1038/s41598-024-59729-6. Sci Rep. 2024. PMID: 38653758 Free PMC article.
-
Aging impairs the osteocytic regulation of collagen integrity and bone quality.Bone Res. 2024 Feb 26;12(1):13. doi: 10.1038/s41413-023-00303-7. Bone Res. 2024. PMID: 38409111 Free PMC article.
References
-
- Seeman E. Bone quality: the material and structural basis of bone strength. J Bone Miner Metab. 2008;26:1–8. - PubMed
-
- Bouxsein ML. Bone quality: where do we go from here? Osteoporos Int. 2008;14(Suppl 5):S118–27. - PubMed
-
- Fyhrie DP, Christiansen BA. Bone material properties and skeletal fragility. Calcif Tissue Int. 2015;97:213–228. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
