Characterisation of meta-analytical functional connectivity in progressive supranuclear palsy

Clin Radiol. 2018 Apr;73(4):415.e1-415.e7. doi: 10.1016/j.crad.2017.11.007. Epub 2017 Dec 18.


Aim: To characterise the meta-analytical functional connectivity patterns in progressive supranuclear palsy (PSP) and compare them to idiopathic Parkinson's disease (IPD).

Materials and methods: It was previously reported that PSP and IPD showed distinct regions of brain atrophy based on voxel-based morphometry (VBM) meta-analysis. Using these regions as seeds, healthy control data were referenced to create and statistically compare meta-analytical functional connectivity maps of PSP and IPD.

Results: Some overlap was noted between the two diseases, including within the thalamus, striatum, and prefrontal cortex; however, the PSP seeds demonstrated more extensive functional co-activity throughout the brain, particularly within the midbrain, precentral gyrus, parietal cortex, basal ganglia, and cerebellum.

Conclusion: These findings may help guide future longitudinal studies in the development of new functional imaging biomarkers for diagnosis and assessing treatment response.

Publication types

  • Meta-Analysis

MeSH terms

  • Brain
  • Brain Mapping / methods*
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Parkinson Disease / diagnostic imaging*
  • Parkinson Disease / physiopathology*
  • Supranuclear Palsy, Progressive / diagnostic imaging*
  • Supranuclear Palsy, Progressive / physiopathology*